Scientific Expertise to Help Solve Technical Roadblocks
During development of a new apheresis device, a client detected higher levels of complement activation than historical experience and were concerned that device development would be slowed down. A BioPhia SME was able to review the data and recommend subsequent experiments that when coupled with a review of the literature could explain the activation and keep the development on track.
Situation:
A client was developing a new apheresis device. Monitoring complement activation after blood exposure, they found higher levels compared to historical experience. The client was concerned this would slow development of the device.
BioPhia Role:
BioPhia was engaged to provide SME review of the in vitro complement activation data and provide insight into possible reasons for the apparent levels and suggest the next steps.
Action:
An initial meeting produced a document that explained the data in the context of extracorporeal blood contact and outlined a set of follow-up experiments to resolve any issues.
Result:
A white paper was generated that included background on complement activation, the original data and results from follow-up work. This was included as an addendum to an internal report on the device development project.